Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion
Abstract The mechanisms of bifurcation, a Truck Model Kit key step in thyroid development, are largely unknown.Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identify a stop-gain mutation in hgfa and two missense mutations in met by positional cloning from these zebrafish lines.The